Chronotherapy

Health

We all have our own internal clock. It follows a 24 hour cycle known as circadian rhythm. Chronotherapy is the practice of timing medication with respect to disease changes related to circadian rhythm. It is believed that Chronotherapy can maximize drug efficacy & minimize adverse effects.

Researchers have identified several seizure patterns linked to natural circadian rhythms &/or wakefulness/sleep cycles. Natural rhythms can alter anti epileptic drug’s (AED’s) digestion, absorption, distribution, metabolism, & excretion. Furthermore, AEDs themselves can modify circadian or diurnal (wake/sleep) patterns. Early trials in humans suggest some epileptic patients may have improved seizure management if their conventional treatment is shifted to chronotherapy.

Keeping a hand written or electronic seizure diary will help identify patterns in seizure activity. My huMom knows from my diaries that quick weather changes or the days around the full moon are times to prepare for me to have an epileptic event. More often than not, my events occur in the early hours of the morning, usually between midnight & 2am, or between 5am & 8am.

Although chronotherapy is in its infancy, it may offer relief to those who appear to have rhythmic breakthrough seizures. New dosing strategies based on your good dog’s natural circadian rhythm may help. We intend to consult my vet about chronotherapy.

CEO Olivia

Now You Know: Probiotics & Prebiotics

News

Hello everyone, Olivia here. Today I have an announcement.

Often my huMom & I are asked questions about living with canine epilepsy, or dog related stuff in general. We are by no means experts & are sure not professionals, but we have done a lot of research & continue to do so.

So starting today, we are trying a weekly blog segment called, “Now You Know”. Readers can send in questions related to canine epilepsy, good health or dog behavior & we will do our best to find an answer. We don’t endorse products but we will speak on their effectiveness or safety.

Today we’ll start with a simple one. What’s the difference between probiotic & prebiotic food for good dogs?

Probiotics are beneficial bacteria that work with the micro flora, or the “good” bacteria, living in the gut. Together, they play critical roles in the breakdown & digestion of food & help keep nasty bugs like E. coli in check. They help populate the intestine with healthy bacteria, boosting the immune system in the digestive tract & through out the body.

Prebiotics are food ingredients that travel undigested to the colon where they ferment & are converted into short chain fatty acids (SCFAs). SCFAs inhibit the growth of harmful bacteria, acting as a source of energy for colon cells & preserving electrolyte & fluid balance; this allows the intestine to move properly. When present in the bowels, prebiotics promote & support healthy digestive flora.

Since prebiotics are essentially feeding micro flora, it’s best to use them in combination with probiotics to support the growth of good bacteria in your good dog’s gut.

Now you know.

You can send your questions to: knottytoys4gooddogs@gmail.com

In the title put, “Now you know question”. My huMom & I will try our best to find an answer & it will appear in a future blog.

CEO Olivia

 

Diet & epilepsy

Health

There is more & more research being done in regards to diet & epilepsy. Correcting nutritional deficiencies can help reduce or control seizures in epileptic dogs, & in some cases, may eliminate seizures completely.

I won’t mince words here, most commercial dog foods are poor quality, especially kibbles. Not only are they lacking in nutrition, they contain chemicals for preserving & often have a high salt content. They are often more grain than anything & dogs aren’t cows.

There are a number of specific nutritional deficiencies in both humans & canines that are known to cause or aggravate seizures, including vitamin deficiencies, mineral deficiencies & amino acid deficiencies. While commercial dog foods are promoted as being nutritional & well-balanced, the fact is, that the process of producing these foods actually destroys the vitamins,minerals & amino acids.

Raw or whole food diets offer the best forms of proteins, amino acids, enzymes, vitamins & minerals. For dogs with epilepsy, a quality diet will go a long way towards controlling or eliminating seizures. That being said, the advantages offered by a raw or whole food diet can only be gained if the diet is well-balanced to the needs of the individual dog. For example, some dog’s can’t eat raw meat due to auto immune deficiencies. Understanding your good dog’s nutritional needs is crucial in creating a diet that will yield positive results. This is especially important for dogs with epilepsy.

There are many recipes online for home made dog food. It may be a little bit more work than tearing open a bag, but your good dog will be healthier & happier that you made the effort.

CEO Olivia